BRCA1 and malignant colon neoplasm: Besides OC, deleterious BRCA1 mutations may also increase a woman’s risk of developing cervical, uterine, pancreatic, and colon cancer.[33, 34] A recent study suggested that promoter hypermethylations, somatic mutations, and genomic deletions of BRCA1 might be responsible for the loss or reduced expression of BRCA1 protein.[35] Here, we analyzed BRCA1 protein expression in SOC patients and found a negativity rate of 29.9 % (29/97).