NMUR2 and obesity due to melanocortin 4 receptor deficiency: The Nmur2 gene is located in a suggestive obesity QTL on chromosome 11, distal to the diabetes QTL Nidd3. Neuromedin U exerts an anorexigenic effect on meal frequency that is blunted in NZO as compared with lean C57BL/6J mice (15 vs. 60 % reduction in C57BL/6J).