INS and hyperinsulinism: As a consequence of the syndrome, male NZO mice develop type 2 like diabetes characterized by marked hyperglycaemia and hyperinsulinemia at earlier age (8–12 weeks), and later on by low serum insulin levels associated with beta-cell destruction (Crofford and Davis 1965; Leiter et al. 1998; Jürgens et al. 2006).