In lean strains such as C57BLKS/J, BTBR T+tf/J or DBA/2 J carrying diabetes susceptibility genes (“diabetes susceptible” background), it can be induced by introgression of the obesity-causing mutations Lep<ob> (ob) or Lepr<db> (db). The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.