ROR1 and lung adenocarcinoma: In lung adenocarcinoma, NKX2-1 (TITF1) has been shown to drive ROR1 expression and the subsequent increase in ROR1 has two distinct proposed functions, including the potentiation of EGF ligand-induced EGFR signaling and the phosphorylation and activation of c-Src regardless of ligand induction (Fig. 1B) (Yamaguchi et al., 2012).