Our study, using the microvesicle profiling approach, has identified differentially regulated peripheral as well as brain-specific candidates (e.g. MBP and glial fibrillary acidic protein(GFAP)) targeting only lacunar stroke while relating them to the long-term outcome measures such as cognitive decline and recurrent vascular events (Table 2, Table S1). The gene discussed is GFAP; the disease is Stroke.