The aim of this present study is to examine the expression of heme oxygenase-1 gene (HMOX1), BTB and CNC homology 1 (Bach-1) as well as miR-122 in liver biopsy specimens obtained from patients with CHC in relation to selected clinical parameters, histological examination and IL-28B polymorphism. This evidence concerns the gene HMOX1 and cryohydrocytosis.