The high expression of Cav-1 in mature adipocytes is something already well established [22] Indeed, previous works from our group had also shown an increase of Cav-1 mRNA and protein expression in whole white adipose tissue [6]–[7], and in isolated adipocytes [8] of rats with a diet-induced model of obesity. Here, CAV1 is linked to obesity due to melanocortin 4 receptor deficiency.