In PH patients with renal insufficiency a cut-off value of 1660 ng/l (sensitivity 68%, specificity 73%; AUC = 0.661; Figure 3A) was identified and NT-proBNP levels above this threshold were significantly associated with unfavorable clinical outcome (p = 0.001, log-rank; Figure 3B). The gene discussed is NPPB; the disease is Renal insufficiency.