Multivariate Cox’s proportional hazards analysis assessing the predictive value of n-terminal pro-brain natriuretic peptide (NT-proBNP) levels on clinical worsening in 40 PH patients with concomitant renal insufficiency (defined as glomerular filtration rate (GFR) ≤60 ml/min/1.73 m2) in a model with further established non-invasive parameters, age and renal function. This evidence concerns the gene NPPB and Renal insufficiency.