Our analysis aimed to assess (1) the impact of renal insufficiency on NT-proBNP levels and (2) the prognostic usefulness of NT-proBNP levels in patients with pre-capillary PH (patients with pulmonary arterial hypertension, PAH, or inoperable chronic thromboembolic PH, CTEPH) and concomitant renal insufficiency. This evidence concerns the gene NPPB and pulmonary arterial hypertension.