PSMD10 and breast carcinoma: To evaluate the potential role of Gankyrin in the development of cervical carcinoma, our CCK8 assay demonstrated that knockdown of Gankyrin could induce a dramatic cell viability reduction in cervical carcinoma cell lines, and the transfection of Gankyrin could also introduce the increasing viability of SiHa and HeLa cell lines, similar proliferative patterns were also observed in pancreatic cancer [13], breast cancer [7] and cholangiocarcinoma [14],these results demonstrate that Gankyrin attributes to various cancer cells proliferation.