Nevertheless, in carcinoma adjacent tissues, we found interestingly that lymph node metastasis rate was 0% (0/10) when nuclei Gankyrin expression stayed positive, however lymph node metastasis rate turned to be 30% (6/20) when nuclei Gankyrin stayed to be negative. This evidence concerns the gene PSMD10 and metastatic malignant neoplasm in the lymph nodes.