Our study found that transfection of Gankyrin could lead to the overexpression of cyclin D1 of cervical cells line, which is consistent with the poliferative activity, also indicating that Gankyrin might accelerate cell cycle progression in cervical carcinoma and implying Gankyrin’s role in tumorigenesis and progression of cervical cancer. The gene discussed is PSMD10; the disease is cervical carcinoma.