The expression of SETD6 was silenced using previously validated shRNAs delivered by lentiviral transduction16 in human breast carcinoma MDA MB231 (ER-, PGR- p53mut), MCF7 (ER+, PGR+ p53wt), and T47D (ER+, PGR+ p53mut) cell lines. The gene discussed is SETD6; the disease is breast carcinoma.