ADAM33 and asthma: Six SNPs (F+1, L−1, S2, T1, T2 and T+1) in ADAM33 were reported to have significant association in seasonal allergic rhinitis (SAR) induced by Japanese cedar pollen [20], while three SNPs (T1, T+1 and V4) were reported to be associated with AR or concomitant AR and Asthma in a Chinese population [12], [21].