CASP3 and neuroblastoma: Quantification of the Western blots showed that the ratio of cleaved caspase-3 to procaspase-3 was increased to 6.72±0.31% in RCAN1.4 overexpressing cells compared with 3.83%±0.22% in control cells with A23187 treatment (p<0.001(Fig. 4B), suggesting that RCAN1.4 overexpression potentiates calcium overloading-induced caspase-3 activation in human neuroblastoma cells.