We have previously shown that adipose tissue-derived human SAA does not influence the development of insulin resistance or adipose tissue inflammation in hSAA1 mice [30] and in this report we show that hSAA1 mice on an ApoE-deficient background develop atherosclerotic lesions to the same extent as their wt littermates in all sections of the aorta. The gene discussed is SAA2; the disease is Insulin resistance.