NPC patients with the treatment of radiotherapy had markedly better overall survival rates than those without the treatment of radiotherapy (p = 0.001).We performed multivariate analysis of CDK4 protein expression levels adjusted for all factors and found that the level of CDK4 expression indicated a tendency as an independent prognostic factor for NPC (P = 0.087) (Table 3). This evidence concerns the gene CDK4 and nasopharyngeal carcinoma.