miRNAs have also been shown to be an essential component of post-mitotic neurones, as DICER knockout in Purkinje cells led to progressive neurodegeneration [72], whilst DICER knockout specifically in post-mitotic postnatal motor neurones was associated with muscular atrophy due to loss of lumbar motor neurones, increased astrogliosis and progressive neurodegeneration. Here, DICER1 is linked to muscular atrophy.