In conclusion, the present meta-analysis, based on 1,521 meningioma patients and 1,523 healthy controls for MTR rs1805087 polymorphism and 1,231 meningioma patients and 1,237 healthy controls for MTRR rs1801394 polymorphism, demonstrated that the MTRR rs1801394 polymorphism is associated with an increased risk of meningioma, whereas the MTR rs1805087 polymorphism is not associated with meningioma. Here, MTRR is linked to meningioma.