FAM107B and ductal breast carcinoma in situ: Considering that HITS expression was lost during the course of tumor progression in terms of TNM grading T-values, we hypothesize that HITS expression declines gradually during the prolonged transition from preneoplastic or early neoplastic lesions, such as ductal carcinoma in situ in the breast, intestinal metaplasia in the stomach, tubular adenoma in the colon and CIN in the uterine cervix, to invasive cancers (Fig. 2).