However, disruption of the IL-2 pathway was shown to result in lymphoid hyperplasia and autoimmunity rather than immune deficiency in mice, indicating that the major function of IL-2 is to limit rather than improve T-cell responses, whereas IL-2 is required for the generation and function of Tregs by upregulating FoxP3 expression (21). The gene discussed is IL2; the disease is Immunodeficiency.