Additionally, Li et al. (21) performed a whole-genome microarray analysis on fibroblast-like cells grown from angiofibromas, periungual fibromas and normal fibroblasts of TSC patients with allelic deletion of TSC2. The EREG gene was found to show the greatest mean elevation in expression in angiofibromas and periungual fibromas (21), thus corroborating with our observation that it is the most downregulated gene upon TSC2 overexpression in both the clones (Supplementary Table S7). This evidence concerns the gene EREG and Angiofibromas.