Major histopathological features associated with AD are senile plaques and neurofibrillary tangles, related to aberrant processing of amyloid precursor protein (APP) leading to the deposition of amyloid β and hyperphosphorylation of tau protein, respectively (Gonzalez-Dominguezet al. 2014, Arnal et al. 2013; Atwood et al. 2000). The gene discussed is APP; the disease is Alzheimer disease.