CASP3 and brain neoplasm: Furthermore, a significantly increased number of cleaved caspase 3 positive cell was observed in brain sections obtained from the mice implanted with UW473shMet-Fmc and MSC-S-TRAIL compared with that of UW473scr-Fmc and MSC-S-TRAIL (Fig.4D), showing the involvement of caspase-mediated apoptosis and further confirming that knock down c-Met overcomes TRAIL-resistance of brain tumor cells in vivo.