In addition to the widely accepted notion that paclitaxel exerts its anti-tumor effect through promoting mitotic arrest in cancer cells and therefore cell death, there is also compelling evidence suggesting that another key mechanism of action of paclitaxel is promoting the activation of caspase signaling pathways, in which caspase 8 has been implicated (Komlodi-Pasztor et al., 2011). Here, CASP8 is linked to cancer.