Given that the duration of CML-CP development by BCR–ABL retrovirus is about 3–4 weeks, and Evi1 alone could induce myelodysplastic syndrome/AML in mice after 6 months or more,39,40 these results indicate that Evi1 can have a causative role in blastic transformation of CML. Here, MECOM is linked to chronic myelogenous leukemia, BCR-ABL1 positive.