Furthermore, we have established multiple CML mice model with Evi1-Internal Ribosomal Entry Site (IRES)-green fluorescent protein (GFP) knock-in allele, in which Evi1-high CML cells can be separated directly and prospectively using a single GFP35 to evaluate their capacity for leukemia development. The gene discussed is MECOM; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.