To clarify the precise behavior of Evi1-high CML LSK cells in vivo, we crossed Evi1+/GFP mice with p210 BCR–ABL transgenic mice (BCR–ABLtg/−),36 which develop a CML-like disease (Supplementary Figure S3a), to analyze undamaged BM of CML-CP (Figure 2e). Here, RUNX1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.