With such a prolonged engraftment, recipients with Evi1-high LSK cells died of CML (4 deaths per 6 mice), while those with Evi1-low LSK cells had no incidence of CML (0 death per 6 mice), revealing high CML-initiating potential of Evi1-high CML LSK cells (Figure 3d). This evidence concerns the gene MECOM and chronic myelogenous leukemia, BCR-ABL1 positive.