As opposed to Evi1-reporter CML models, in AML model by MLL-ENL retrovirus, Evi1-high MLL-ENL leukemic cells showed no advantage in leukemia initiation compared with Evi1-low cells (Supplementary Figure S5). The gene discussed is KMT2A; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.