To evaluate the stem cell activity of Evi1-high CML LSK cells in vivo, we next performed BM transplantation (BMT) experiments, in which 5 × 103 Evi1-high or Evi1-low LSK cells were injected intravenously into sublethally irradiated recipients (Figure 3a). Here, RUNX1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.