To evaluate a leukemogenic function of Evi1-high cells in CML-BC, BCR–ABL and NUP98–HOXA9 were co-transduced37 into 5FU-primed BM of Evi1+/GFP mice to establish Evi1-reporter CML-BC mice (Figure 4a). This evidence concerns the gene RUNX1 and breast cancer.