KL and Huntington disease: We observed no differences in phosphorus and vitamin D in our three CACs groups, so we suggest that circulating FGF23 may have a protective effect on arterial wall integrity and that rising FGF23 levels in HD patients are in part a consequence of vascular resistance to FGF23, because of uremia-mediated down-regulation of Klotho expression in vascular cells [77], [78].