Pathologically, serum sCD40L was not significantly correlated with T-stage (γs = 0.194, p = 0.156), lymph node metastasis (γs = -0.146, p = 0.289), or tumor size (γs = 0.035, p = 0.801). Here, CD40LG is linked to metastatic malignant neoplasm in the lymph nodes.