Other genes, including ATP5A, BCR, FGFR4, PDPK1, PIP5K1C, RIOK3, and SRC, also act to regulate TRAIL-induced apoptosis, but their potential to overcome resistance to TRAIL-induced cytotoxicity when inhibited may be more context specific (that is, in a more-restricted subset of breast cancer cells). This evidence concerns the gene RIOK3 and breast cancer.