They correlated its downregulation to the alteration of hepatic lipid metabolism genes, implicated in NASH development, such as fatty acid synthase (FAS), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), sterol regulatory element-binding protein-1c (SREBP-1c), and sterol regulatory element-binding protein 2 (SREBP-2). Here, SREBF2 is linked to metabolic dysfunction-associated steatohepatitis.