CDKN2A and hepatocellular carcinoma: Also, the expression of let-7g was downregulated in human HCC cell lines; in line with this finding, after transfection experiments in hepatocarcinoma cells, it was suggested that let-7g may act as tumor suppressor gene that inhibits HCC cell proliferation by downregulating c-Myc and upregulating the tumor suppressor gene p16(INK4A) [103], whereas other members of this family, such as let-7a/b, were found to be upregulated in human hepatocellular CSCs, representing possible molecular targets for eradication of hepatocarcinoma [97].