Finally, the p53/miR-34 axis is at the core of a regulatory network targeting the oncogenic Wnt signaling pathway, responsible for the snail family zinc finger 1 (Snail1) protein-dependent epithelial-mesenchymal transition (EMT) program in a miR-34/UTR-specific manner [62]; EMT, in fibrotic and cirrhotic livers, has important implications for the progression to HCC [63, 64]. The gene discussed is SNAI1; the disease is hepatocellular carcinoma.