AKT1 and endometrial cancer: In the case of endometrial cancer cells, the PI3K/AKT/mTOR signal transduction cascade constitutes one of the main activation pathways of tyrosine kinase receptors such as vascular endothelial growth factor receptor 1 (VEGFR-1), platelet-derived growth factor receptor (PDGFR-α), epidermal growth factor receptor 1 (EGFR-1), and c-MET [31].