ADD1 and hypertensive disorder: It was similar to other research that the concentration of AST was inversely correlated with ADD1 CpG2-5 methylation levels in female nonessential hypertension [22], and the level of methylation in gene-specific DNA is associated with serum levels of C-reactive protein [23] as well as the levels of Triglycerides and fatty acids in abdominal adipose tissue [24].