And we observed that the level of DNA methylation might be affected by some clinical marks (Table 6), such as TBIL, LEVF, Albumin, and AST in P2Y12 CpG 1 with alcohol abuse (F = 9.302, PF value = 0.001, R square = 0.724); LEVF, Albumin, and AST in P2Y12 CpG 2 with alcohol abuse (F = 10.033, PF value = 0.001, R square = 0.667); LEVF and TBIL in P2Y12 CpG 1 with current smoking (F = 6.193, PF value = 0.005, R square = 0.251); and LEVF, CRP, BUN, and Triglycerides in P2Y12 CpG 1 with Albumin < 35 (F = 14.345, PF value < 0.001, R square = 0.840). This evidence concerns the gene P2RY12 and alcohol abuse.