Again given the low incidence of RET-rearranged of NSCLC (~2%) and the potential crowded market for RET inhibitors, it is unlikely manufacturer of any one of the six potential marketed RET inhibitors will sponsor such as a trial, lest it will allow competitors to piggyback on the CDx to gain approval of their TKIs without shouldering the cost for patient screening and developing an approvable CDx. Here, RET is linked to non-small cell lung carcinoma.