Leukopenia, diarrhea, neutropenia, proteinuria, increased aspartate aminotransferase, stomatitis, fatigue, thrombocytopenia, increased alanine aminotransferase, hypertension, decreased weight, decreased appetite, epistaxis, abdominal pain, dysphonia, increased serum creatinine, and headache were the most commonly observed AEs with aflibercept (all grades ≥20% incidence, ≥2% between arm difference). The gene discussed is GPT; the disease is Decreased total leukocyte count.