As a consequence, IFN‐γ/IL‐4 ratio (index of Th1/Th2 cell balance) resulted significantly higher in ischemic quadriceps (7.3‐fold), and gastrocnemius (3.8‐fold) muscles during early phase of ischemia (P < 0.05 vs. respective nonischemic muscles; Fig. 7C). Here, IFNG is linked to ischemia.