Based on these results, calculation of CD11c to CD206 ratio (index of M1/M2 macrophage balance) resulted significantly higher both in quadriceps (4.9‐fold, P < 0.05), and gastrocnemius (5.4‐fold, P < 0.01) ischemic muscles, compared to nonischemic ones, during early stage of limb ischemia. Here, MRC1 is linked to limb ischemia.