A significant group by AT depot interaction was observed for leptin, MCP‐1,VCAM‐1, PAI‐1, CD4, CD8, CD11c, F4/80, FoxP3, nNOS, p22phox, and p47hpox mRNA.A significant group by condition by AT depot interaction was only observed for IL‐6 mRNA.Figure 11 illustrates the effects of obesity andL‐NAME treatment on citrate synthase activity in the retroperitoneal AT. Here, CD8A is linked to obesity due to melanocortin 4 receptor deficiency.