A significant group by AT depot interaction was observed for leptin, MCP‐1,VCAM‐1, PAI‐1, CD4, CD8, CD11c, F4/80, FoxP3, nNOS, p22phox, and p47hpox mRNA.A significant group by condition by AT depot interaction was only observed for IL‐6 mRNA.Figure 11 illustrates the effects of obesity andL‐NAME treatment on citrate synthase activity in the retroperitoneal AT. This evidence concerns the gene CYBA and obesity due to melanocortin 4 receptor deficiency.