Importantly, in addition to providing evidence of phenotypic divergence among ATdepots, here we show that the effects of hyperphagia‐induced obesity on AT gene expression(leptin, MCP‐1, VCAM‐1, PAI‐1, CD4, CD8, CD11c, F4/80, FoxP3, nNOS,p22phox, and p47hpox mRNA) appear to be heterogeneous across fat pads. The gene discussed is SERPINE1; the disease is obesity due to melanocortin 4 receptor deficiency.