APOE and atherosclerosis: In addition, there is evidence that mice with targeted disruption of the eNOS geneexhibit abnormal vascular remodeling in response to external carotid artery ligation (Rudic et al.1998), and mice with eNOS/apoE double knockout exhibitaccelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease (Kuhlencordt etal.