In the HFD‐fed mouse model, increases in fasting blood glucose levels and plasma insulin levels have been reported to appear already after 1 week of HFD, resulting in a stable hyperglycemia and a progressively increased hyperinsulinemia over time (Ahren and Pacini 2002); Winzell and Ahren 2004). The gene discussed is INS; the disease is Hyperinsulinemia.