The SFO mediates the hypertension resulting from chronic infusion of low doses of angiotensin II, which acts in part via sympathoexcitation (Zimmerman et al. 2004; Collister and Hendel 2005, and WD can increase the expression of angiotensin II AT1 receptors in the SFO (Sanvitto et al. 1997. Here, AGT is linked to hypertensive disorder.