For example, S1PR3 is related to fibrosis in cardiac ventricular fibroblasts (Takuwa et al. 2010), S1PR2 is involved in a diabetic nephropathy model (Huang et al. 2012), and a relationship has been found between S1PR3 and fibrosis in myofibroblasts (Keller et al. 2007). This evidence concerns the gene S1PR2 and diabetic kidney disease.