AGT and glomerulosclerosis: The combined effects of interstitial inflammation, oxidative stress, and local angiotensin II activity result in the disruption of glomerulus‐tubule continuity, the development of pathogenic hypoxia, the generation of myofibroblasts and interstitial fibrosis, and impairments in the protective autoregulation of glomerular blood flow that leads to glomerulosclerosis Mitobe et al. (2010).