Active caspase-1 can eventually process IL-1β and IL-18 precursors, serving as enhancer of multiple proinflammatory pathways including NF-κB, mitogen-activated protein kinase (MAPK), IFNγ, chemokines, and ROS and also promoting insulin resistance [49] (Figure 1(b)). This evidence concerns the gene NFKB1 and Insulin resistance.