INS and type 2 diabetes mellitus: While many loci appear to contribute broadly to T2D risk, some loci have currently been confirmed in European populations only, including WFS1, NOTCH2, THADA, ADAMTS9, TSPAN8/LGR5, INS-IGF2, ADCY5, GCK, MTRNR1B, HMGA2, HNF1A, ZBED3, KLF14, ZFAND6, PRC1, TLES/CHCHD9, and RBMS1 [109, 116, 153–155].