INS and obesity due to melanocortin 4 receptor deficiency: Three of these genes have unknown function (RBMS1, PTPRD, and SRR) [117, 118], while RPS12, LIMK2, and AUH are associated with diabetic nephropathy [121], C2CD4A is associated with β-cell dysfunction [119, 122], SPRY2 is associated with obesity and insulin resistance [120, 123], and SASH1 is associated with insulin growth factors [121].