Hence, centrally (astrocyte-restricted) [26] and total IL-6 deficiency in mice [33–35] are associated with increased body weight and adiposity at young and late ages, while long-term central (intracerebroventricular) but not peripheral IL-6 treatment exerts a restorative effect on fat mass values [36]. Here, IL6 is linked to hyperinsulinemic hypoglycemia, familial, 4.