In a recent paper evaluating the role of androgen signalling in epithelial-mesenchimal transition, Zhu and Kyprianou [36] demonstrated that overexpression of AR in PCa cell lines suppresses androgen-induced epithelial-mesenchimal transition, suggesting that downregulation of AR occurring in androgen-deprived condition [37] may facilitate mesenchimal transition and promote metastasis [36]. This evidence concerns the gene AR and posterior cortical atrophy.