More recently, it has been argued that incorporation of UNG2 into HIV-1 particles may not be detrimental for virus infection in target cells but rather has a positive impact on virus replication and virus infectivity achieved through a non-enzymatic mechanism mapping within a 60-amino-acid long domain located in the N-terminal region of UNG2 (Guenzel et al., 2012). Here, UNG is linked to viral infectious disease.