Task-related hyperactivity has been described in asymptomatic carriers of AD pathological mutations during associative encoding task (right anterior hippocampus; Quiroz et al., 2010); in asymptomatic offspring of autopsy-confirmed AD patients (Bassett et al., 2006); in cognitively intact young and old carriers of APOE4 (Bookheimer et al., 2000; Dickerson et al., 2005; Filippini et al., 2009) and in low-performing clinically healthy aged individuals (Miller et al., 2008). Here, APOE is linked to Alzheimer disease.