For example, all of the members of the Shank protein family that indirectly link NMDAR and mGluR were identified as autism causative genes (Durand et al., 2007; Hung et al., 2008; Berkel et al., 2010; Pinto et al., 2010; Peca et al., 2011; Sato et al., 2012; Schmeisser et al., 2012; Won et al., 2012). This evidence concerns the gene SHANK2 and autism.