Another example of the general applicability and beneficial effects of PTEN deletion in PD mouse models is the enhanced survival, function and integration of grafted PTEN−/− dopaminergic neurons within the striatum of MitoPark mice, a model that shows progressive parkinsonism after specific inactivation of the mitochondrial respiratory chain in midbrain dopaminergic neurons (Zhang et al., 2012b). Here, PTEN is linked to Parkinson disease.