Active research using molecular interaction simulation and modeling approaches, as well as functional screening of PTEN mutations in cell-based assays (Rodríguez-Escudero et al., 2011; Lumb and Sansom, 2013; Nguyen et al., 2013), will no doubt prove helpful in further clarifying the effects of PTEN mutations associated with PHTS. The gene discussed is PTEN; the disease is PTEN hamartoma tumor syndrome.