Subsequent studies using a tamoxifen-inducible Nestin-Cre:Ptenloxp/loxp mouse model, in order to delete PTEN specifically in postnatal neural stem cells in the subgranular zone of hippocampal dentate gyrus, recapitulated the general overgrowth phenotype seen in other models and some, but not all of the impairments associated with autism (Amiri et al., 2012). This evidence concerns the gene PTEN and autism.