In several cancer types, nuclear localization is a contributory factor to PTEN's tumor suppressor activity, for example, by maintaining chromosomal integrity (Shen et al., 2007), and regulating cellular survival (Chung et al., 2005; Gil et al., 2006), cell cycle, and DNA repair responses (Shen et al., 2007; Song et al., 2011; Bassi et al., 2013). The gene discussed is PTEN; the disease is neoplasm.