sEPCR binding to APC blocks phospholipid interaction and alters the active site of APC.Inherited defects of the PC pathway are associated withan increased tendency for venous thromboembolism(VTE) [14], whereas low plasma sEPCR (sEPCR<30 ng/ml) appears to reduce the risk of thrombosis [15]. The gene discussed is APC; the disease is venous thromboembolism.