While intracerebral hemorrhagia may bemostly seen in FX and FXIII, afibrinogenemia, and FVIIdeficiency, musculoskeletal bleeding (hemarthrosis andhematoma) more frequently occurs in afibrinogenemia,and FX, FXI, and FXIII deficiency [2,6,7,8]. This evidence concerns the gene F11 and Familial afibrinogenemia.