Moreover, the associationbetween HLA class II alleles and the FVIII inhibitorsin Thai hemophilia patients was further investigated inthis study, as recent studies have indicated that inhibitorformation depends upon an adequate T-cell responseby major histocompatibility complex class II moleculesto FVIII resulting from the presentation of FVIII proteinantigen to T-cell receptors [18-21]. Here, F8 is linked to hemophilia.