A comparison of thefrequency data for DRB1*15/16 in hemophilia A patientswith FVIII inhibitor reported in other studies showed thatDRB1*15 and DRB1*16 were high-risk alleles for inhibitorformation in patients with congenital hemophilia Aand acquired hemophilia A, respectively [8-10]. The gene discussed is HLA-DRB1; the disease is hemophilia A.