CCNA1 and chronic myelogenous leukemia, BCR-ABL1 positive: Koeffler et al. comparedthe expression of cyclin A1 in normal and leukemichematopoietic cell lines using RT-PCR and reported thatthis cyclin was overexpressed in the leukemic lines [42].Kramer et al. used RT-PCR and reported that cyclin A1was present in 84 of 113 CML patients [32].