CDKN2A and chronic myelogenous leukemia, BCR-ABL1 positive: In addition, while cyclin D expression was significantlyhigher during the G0/G1 phase than during the Sphase in the CML group, expression of its inhibitor (p16)was lower during the G0/G1 phase than during the otherphases, suggesting an imbalance that facilitates leukemicprogression.