As such, the present study aimed toidentify mutations in exon 11 of the c- kit gene in Indianpatients with malignant leukemias (acute myeloid leukemia[AML ], acute lymphoblastic leukemia [ALL], chronicmyeloid leukemia [CML ] and chronic lymphocytic leukemia[CLL ]) and to determine if c-kit gene mutations couldbe used as molecular genetic markers for leukemia. This evidence concerns the gene KIT and chronic myelogenous leukemia, BCR-ABL1 positive.