As such, the present study aimed toidentify mutations in exon 11 of the c- kit gene in Indianpatients with malignant leukemias (acute myeloid leukemia[AML ], acute lymphoblastic leukemia [ALL], chronicmyeloid leukemia [CML ] and chronic lymphocytic leukemia[CLL ]) and to determine if c-kit gene mutations couldbe used as molecular genetic markers for leukemia. The gene discussed is KIT; the disease is B-cell chronic lymphocytic leukemia.