It is known that c-kit is a leukemia proto-oncogeneand that activated c-kit mutations are likely to contributeto the development of leukemia in humans [7,10].The activation sphere of the c-kit receptor has resulted inconstitutive c-kit kinase activity and c-kit receptors thatharbor such mutations when introduced into mammaliancells in the downstream signaling pathways lead to factorindependentgrowth in vitro and leukemogenesis in vivo[7,11]. The gene discussed is KIT; the disease is leukemia.