Accordingly, targeted deletion of miR-31 results in the repression of nonsmall cell lung cancer cells growth and in vivo tumorigenicity due to higher expression of LATS2 (human large tumor suppressor 2) and PPP2R2A (PP2A regulatory subunit B alpha isoform) [91]. LATS 2 encodes a putative serine/threonine kinase that exerts tumor-suppressive effects by inhibition of the G1/S cell cycle transition [92]. The gene discussed is PPP2R2A; the disease is lung cancer.