Other angiogenesis-related proteins are also regulated by miRNAs, for example, ectopic expression of miR-381 reduced at mRNA and protein level a putative stem cell gene ID1 (inhibitor of differentiation 1), involved in invasion and angiogenesis, and thus significantly decreased lung cancer cells migration and invasion [149], whereas ectopic expression of miR-26a enhances lung cancer metastasis potential via modulation of metastasis-related genes, among them matrix metallopeptidase 2 (MMP-2) [150]. The gene discussed is ID1; the disease is lung cancer.