Two additional miRNAs, miR-221 and miR-222, impair TRAIL-induced apoptosis, thus transfection blocking these miRNAs with anti-miR-221 and anti-miR-222 results in TRAIL-sensitivity in NSCLC, a mechanism involving the downregulation of p27, demonstrating that high expression of miR-221 and miR-222 maintains the TRAIL-resistant phenotype [101]. Here, CDKN1B is linked to non-small cell lung carcinoma.