CDKN1A and lung cancer: However, it was demonstrated that several miRNAs affect cell cycle progression at different phases of cell cycle acting on members of Kip/Cip family. Let-7a elevates p21 (CDKN1A) levels via UHRF2 (ubiquitin-like with PHD and ring finger domains 2) inhibition and suppresses the growth of A549 lung cancer cells [41], whereas miR-128-2 posttranscriptionally targets E2F5 and leads to the abrogation of its repressive activity on p21 (waf1) transcription in a human NSCLC cell line (H1299) [81].