Corroborated by their earlier reports [158, 157, 136], Tennis et al. concluded that Spry4 represents an inducible effector of the Wnt7A/Fzd9 pathway downstream of PPARγ which restores a nontransformed epithelial phenotype while inhibiting NSCLC cell growth, migration, and invasion [56]. The gene discussed is FZD9; the disease is non-small cell lung carcinoma.