Moreover, although ectopic expression of Spry2 inhibited ERK activity and diminished cell migration in NSCLC cells with WT KRAS, but not in those with the mutated one, it significantly reduced cell proliferation in all NSCLC cell lines studied in vitro and blocked tumor formation in mice inoculated with the KRAS-mutated cell line A-549. The gene discussed is SPRY2; the disease is non-small cell lung carcinoma.