Identifying Spry2 as an inducible, negative regulator of HGF/SF-induced activation of ERK and AKT, Lee et al. [63] reported in 2004 that Spry2 inhibits proliferation, anchorage-independent growth, migration, and invasion of SK-LMS-1 human leiomyosarcoma cells in vitro. This evidence concerns the gene SPRY2 and leiomyosarcoma.