They observed in a collection of human liver tissue samples the significant downregulation of Spry2 protein as well as ubiquitously high expression of c-Met (total and activated) and its downstream effectors (activated Erk and Akt) in most cases of HCC with poorer outcome (HCCP) in the context of WT Ras. The gene discussed is AKT1; the disease is hepatocellular carcinoma.