SPRY1 and cancer: In a study by Lo et al. in 2004, although mSpry1 and mSpry2 were implicated in the breast development during puberty and pregnancy [21], it was revealed in Cancer Profiling Array containing pairs of complementary DNAs (cDNAs) generated from 50 matched pairs of normal and cancer tissues that hSpry1 and hSpry2 were consistently downregulated in breast cancer.