SPRY2 and malignant colon neoplasm: In a study by Barbachano et al. [69], immunofluorescence analysis of human colon cancer biopsies quantitatively confirmed in 34 patients showed high levels of Spry2 and low levels of E-cadherin in undifferentiated, high-grade tumors in contrast to low levels of Spry2, and high levels of E-cadherin in low-grade specimens.