Later, Fritzsche et al. [149] observed through microarray analysis of microdissected prostate tissue specimens a coordinated, yet modest, downregulation of both Spry1 and Spry2 mRNAs gradually increasing from hyperplasia to severe prostatic intraepithelial neoplasia (PIN) to cancer. The gene discussed is SPRY2; the disease is prostate intraepithelial neoplasia.