Nevertheless, context-dependent contribution of Sprouty to cancer tumorigenicity and metastatic potential has also been reported in colon cancer [68, 69], as well as in RAS mutated fibrosarcoma [141] and rhabdomyosarcoma [70] as a result of E-cadherin repression and ensuing inhibition of the adhesive epithelial phenotype [69], upregulation of c-Met [68], and a concomitant RAS mutation [70, 141]. Here, MET is linked to malignant colon neoplasm.