Indicating Spry2-dependent interaction of H-Ras with c-Cbl and CIN85, and the ability of Spry2 to sustain EGFR signaling and tumor formation in the context of HRAS activation, they indicated that the positive effect of Spry2 in sarcoma tumor formation by human fibroblasts is specific to HRAS transformation. The gene discussed is HRAS; the disease is sarcoma.